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Ghrelin and motilin are cosecreted from a prominent endocrine cell population in the small intestine
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Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Efficacy of mitemcinal, a motilin agonist, on gastrointestinal symptoms in patients with symptoms suggesting diabetic gastropathy: a randomized, multi-center, placebo-controlled trial
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ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2007)
Mitemcinal (GM-611), an orally active motilin agonist, facilitates defecation in rabbits and dogs without causing loose stools
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Contractile effects of ghrelin-related peptides on the chicken gastrointestinal tract in vitro
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Motilin activates neurons in the rat amygdala and increases gastric motility
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PEPTIDES (2007)
Delineation of the motilin domain involved in desensitization and internalization of the motilin receptor by using full and partial antagonists
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In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine
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Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs
Ken-ichi Ozaki et al.
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Discovery of a new class of macrocyclic antagonists to the human motilin receptor
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JOURNAL OF MEDICINAL CHEMISTRY (2006)
Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse
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Synthesis and SAR of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives as non-peptidic motilin receptor antagonists
Sigmond G. Johnson et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity
B Matsuura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Influence of motilin on gastric fundus tone and on meal-induced satiety in man: Role of cholinergic pathways
R Cuomo et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2006)
Influence of ghrelin on interdigestive gastrointestinal motility in humans
J Tack et al.
GUT (2006)
Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract
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JOURNAL OF GASTROENTEROLOGY (2006)
Effect of atilmotin on gastrointestinal transit in healthy subjects: a randomized, placebo-controlled study
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Motilin inhibits ganglionic transmission in the myenteric plexus of the guinea-pig ileum
Y Katayama et al.
NEUROSCIENCE RESEARCH (2005)
Motilin and erythromycin-A share a common binding site in the third transmembrane segment of the motilin receptor
L Xu et al.
BIOCHEMICAL PHARMACOLOGY (2005)
Desensitization of the human motilin receptor by motilides
L Thielemans et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Demonstration of a specific site of covalent labeling of the human motilin receptor using a biologically active photolabile motilin analog
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Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro
I Depoortere et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2005)
Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus
L Xu et al.
REGULATORY PEPTIDES (2005)