期刊
BMC NEPHROLOGY
卷 15, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1471-2369-15-55
关键词
Bicarbonate; Dietary acid; Net endogenous acid production; Sodium bicarbonate; Alkali; Ammonia; Complement; Endothelin; Aldosterone
资金
- American Society of Nephrology Carl W. Gottschalk Research Scholar Grant
- National Institutes of Health (NIH) [T32 DK007110]
- Clinical and Translational Science Award (CTSA) [1 UL1 TR001073-01, 1 TL1 TR001072-01, 1 KL2 TR001071-01]
- National Center for Advancing Translational Sciences (NCATS)
- component of the NIH
Metabolic acidosis is a common complication of chronic kidney disease. Accumulating evidence identifies acidosis not only as a consequence of, but as a contributor to, kidney disease progression. Several mechanistic pathways have been identified in this regard. The dietary acid load, even in the absence of overt acidosis, may have deleterious effects. Several small trials now suggest that the treatment of acidosis with oral alkali can slow the progression of kidney disease.
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