期刊
EUROPEAN ADDICTION RESEARCH
卷 21, 期 2, 页码 63-70出版社
KARGER
DOI: 10.1159/000366018
关键词
Prenatal exposure; Cognitive development; Visual attention; Methadone; Buprenorphine; Opioid maintenance therapy; Children; Child development
资金
- Norwegian Directorate for Children, Youth and Family Affairs [13/60525]
- Norwegian Research Council
Aims: To examine whether prenatal exposure to opioid agonist medication is associated with visual selective attention and general attention problems in early childhood. Method: Twenty-two children (mean age = 52.17 months, SD = 1.81) prenatally exposed to methadone, 9 children (mean age = 52.41 months, SD = 1.42) prenatally exposed to buprenorphine and 25 nonexposed comparison children (mean age = 51.44 months, SD = 1.31) were tested. Visual selective attention was measured with a Tobii 1750 Eye Tracker using a spatial negative priming paradigm. Attention problems were measured using the Child Behavior Checklist. Results: The comparison group demonstrated a larger spatial negative priming effect (mean = 23.50, SD = 45.50) than the exposed group [mean = -6.84, SD = 86.39, F (1,50) = 5.91, p = 0.019,. 2 = 0.11]. No difference in reported attention problems was found [F (1,51) = 1.63, p = 0.21,. 2 = 0.03]. Neonatal abstinence syndrome and prenatal exposure to marijuana were found to predict slower saccade latencies in the exposed group (b = 54.55, SE = 23.56, p = 0.03 and b = 88.86, SE = 32.07, p = 0.01, respectively). Conclusion: Although exposed children did not appear to have attention deficits in daily life, lower performance on the SNP task indicates subtle alteration in the attention system. (C) 2014 S. Karger AG, Basel
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