期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 3, 期 41, 页码 8032-8058出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb01276g
关键词
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资金
- Ministry of Science and Technology, Taiwan [102-2221-E-008-112-MY2, 103-2120-M-008-001, 104-2221-E-008-107-MY3]
- LandSeed Hospital project [NCU-LSH-101-A-001, NCU-LSH-102-A-003]
- National Defense Medical Center Project [102NCU-NDMC-01]
- Cathay General Hospital Project [104CGH-NCU-A3]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [15K06591]
- Grants-in-Aid for Scientific Research [15K06591] Funding Source: KAKEN
Both human pluripotent stem cells (hPSCs) from embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have the potential ability to differentiate into many different cell types originating from all three germ layers. This review discusses physical cues from natural and synthetic biomaterials that guide the differentiation of hESCs and hiPSCs into several different lineages. We place special focus on how the hPSC differentiation fate is affected by (a) the elasticity of biomaterials used for hPSC culture, (b) the topography of biomaterials used for hPSC culture, and (c) the mechanical forces associated with biomaterials (stretching and electrical stimulation via biomaterials) used for hPSC culture.
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