期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 3, 期 14, 页码 2770-2777出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb01953a
关键词
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资金
- National Health and Medical Research Council (NHMRC) [GNT1047576, GNT1090898]
The anti-biofilm effect of drug delivery systems composed of the antiseptic quaternary ammonium compound cetylpyridinium chloride (CPC) and cholesterol was evaluated in Staphylococcus aureus biofilm. Self-assembly of CPC/cholesterol to approximately 100 nm CPC-quatsomes was successfully accomplished by a simple sonication/dispersion method over a broad concentration range from 0.5 to 10 mg ml(-1) CPC. CPC-quatsomes showed a dose-dependent anti-biofilm effect, killing >99% of biofilm-associated S. aureus from 5% mg ml(-1) after 10 minutes exposure. Cell toxicity studies with CPC-quatsomes in Nuli-1 cells revealed no adverse effects at all tested CPC concentrations. CPC-quatsomes, therefore, have a promising potential as novel drug delivery systems with built-in anti-biofilm activity.
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