4.6 Article

Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

期刊

JOURNAL OF MATERIALS CHEMISTRY B
卷 3, 期 25, 页码 4993-4996

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb00458f

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资金

  1. National Basic Research Program of China (973 Program) [2013CB834701]
  2. University Grants Committee of Hong Kong [AoE/P-03/08]
  3. Research Grants Council of Hong Kong [604913/6301614, N_HKUST604/14]
  4. Innovation and Technology Commission [ITCPD/17-9]
  5. Guangdong Innovative Research Team Program of China [201101C0105067115]

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Two azide-functionalized tetraphenylethene derivatives with AIE features are synthesized and used as fluorescent agents for detecting S-phase DNA synthesis and cell proliferation based on EdU assay. Compared to the Alexa-azide dye, a commercial DNA bioprobe, the AIE fluorogens show better photostability and sensitivity, making them promising alternatives.

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