The design and synthesis of acrylato and imino derivatives of calix[4]arene for applications in static and dynamic combinatorial libraries

The synthesis of novel calix[4]arene tetra-acrylates and the potential use of macrocyclic platforms in the development of static and dynamic combinatorial libraries (DCL) using reversible imine formationare described. Using such a macrocyclic platform in DCL formation results in a large number of library members while keeping the number of building blocks in the library to a minimum number.