期刊
CHEMICAL SCIENCE
卷 5, 期 6, 页码 2416-2421出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc00652f
关键词
-
资金
- AstraZeneca
- University of Bristol
- EPSRC [EP/G036764/1, EP/J007455/1]
- EPSRC [EP/K03927X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/J007455/1, 981192, EP/K03927X/1, 1100702] Funding Source: researchfish
Copper catalyzed Heck-like cyclizations of oxime esters are described. Mechanistic studies indicate a reaction pathway that proceeds via the generation and cyclization of an intermediate that possesses iminyl radical character. To the best of our knowledge, this work encompasses the first examples of Cu-catalyzed aza-Heck reactions that proceed via oxidative initiation at nitrogen to generate products containing a new alkene. This new protocol is also an effective alternative to Pd-based systems and highlights the value of replacing precious metal catalysts with cheaper and more sustainable variants.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据