期刊
CHEMICAL SCIENCE
卷 5, 期 2, 页码 625-630出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc51930a
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资金
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore)
Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anticancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.
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