期刊
CHEMICAL SCIENCE
卷 5, 期 2, 页码 501-506出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc52806e
关键词
-
资金
- NIH [R01GM031332, RR027690]
The Z-selective cross metathesis of allylic-substituted olefins is explored with recently developed ruthenium-based metathesis catalysts. The reaction proceeds with excellent stereoselectivity for the Z-isomer (typically >95%) and yields of up to 88% for a variety of allylic substituents. This includes the first synthesis of Z-alpha,beta-unsaturated acetals by cross metathesis and their elaboration to Z-alpha, beta-unsaturated aldehydes. In addition, the reaction is tolerant of a variety of cross partners, varying in functionality and steric profile.
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