期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 3, 期 32, 页码 6599-6604出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb00834d
关键词
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资金
- Leverhulme Trust [RPG-2013-017]
- Commission of Higher Education (Thailand)
- Thailand Research Funds through the Royal Golden Jubilee PhD Program [PHD/0001/2553]
Thiol-bearing microgels have been synthesised from copolymerisation of 2-(acetylthio)ethylacrylate and 2-hydroxyethylmethacrylate, and subsequent deprotection using sodium thiomethoxide. The concentration of thiol groups on these microgels could be tailored by use of different molar ratios of the two monomers. These thiol-bearing microgels were shown to adhere to ex vivo porcine urinary bladder, which was correlated with their level of thiolation. By simply mixing solutions of thiol-bearing microgels and doxorubicin, high levels of drug loading into the microgels could be achieved. Thiol-bearing microgels controlled the release of doxorubicin in a time-dependent manner over several hours. These doxorubicin-loaded thiol-bearing microgels could have application in the treatment of early-stage bladder cancers. The method used represents a new 'bottom-up' approach for the synthesis of novel mucoadhesive microgels.
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