期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 3, 期 45, 页码 8757-8770出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb00450k
关键词
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资金
- National Institute of Health [2R01AR055650, 1R01AR063717]
- Stanford Department of Orthopaedic Surgery
- NIH [R01DE024772-01]
- California Institute of Regenerative Medicine Tools and Technologies Awards
- National Science Foundation (NSF) CAREER Award
- Stanford Child Health Research Institute Faculty Scholar Award
- Stanford Child Health Research Institute
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR055650, R01AR063717] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE024772] Funding Source: NIH RePORTER
Since its introduction in the early 1990s, layer-by-layer (LbL) self-assembly of films has been widely used in the fields of nanoelectronics, optics, sensors, surface coatings, and controlled drug delivery. The growth of this industry is propelled by the ease of film manufacture, low cost, mild assembly conditions, precise control of coating thickness, and versatility of coating materials. Despite the wealth of research on LbL for biomolecule delivery, clinical translation has been limited and slow. This review provides an overview of methods and mechanisms of loading biomolecules within LbL films and achieving controlled release. In particular, this review highlights recent advances in the development of LbL coatings for the delivery of different types of biomolecules including proteins, polypeptides, DNA, particles and viruses. To address the need for co-delivery of multiple types of biomolecules at different timing, we also review recent advances in incorporating compartmentalization into LbL assembly. Existing obstacles to clinical translation of LbL technologies and enabling technologies for future directions are also discussed.
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