期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 3, 期 30, 页码 6355-6367出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb00501a
关键词
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资金
- Foundation for Science and Technology (FCT) Portugal
- QREN
- program FEDER/COMPETE through Centre of Chemistry (CQ-UM) of University of Minho
- FCT [SFRH/BD/38766/2007, SFRH/BD/72651/2010, SFRH/BD/79195/2011, Rede/1517/RMN/2005]
- European Social Fund
- Fundação para a Ciência e a Tecnologia [SFRH/BD/79195/2011, SFRH/BD/38766/2007, SFRH/BD/72651/2010] Funding Source: FCT
Supramolecular hydrogels rely on small molecules that self-assemble in water as a result of the cooperative effect of several relatively weak intermolecular interactions. Peptide-based low molecular weight hydrogelators have attracted enormous interest owing to the simplicity of small molecules combined with the versatility and biocompatibility of peptides. In this work, naproxen, a well known non-steroidal anti-inflammatory drug, was N-conjugated with various dehydrodipeptides to give aromatic peptide amphiphiles that resist proteolysis. Molecular dynamics simulations were used to obtain insight into the underlying molecular mechanism of self-assembly and to rationalize the design of this type of hydrogelators. The results obtained were in excellent agreement with the experimental observations. Only dehydrodipeptides having at least one aromatic amino acid gave hydrogels. The characterization of the hydrogels was carried out using transmission electron microscopy (TEM), circular dichroism (CD), fluorescence spectroscopy and also rheological assays.
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