期刊
CHEMICAL SCIENCE
卷 5, 期 1, 页码 117-122出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc51831k
关键词
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资金
- National Basic Research Program of China [2012CB215500, 2012CB821600]
- National Natural Science Foundation of China [20825209, 21202189]
- Chinese Academy of Sciences
- Syngenta PhD Studentship
An efficient and direct monofluoromethylation of O-, S-, N-, and P-nucleophiles with PhSO(NTs) CH2F 1 has been developed. In contrast to the previously known detrimental effect of a-fluorine substitution on S(N)2 reactions, the current monofluoromethylation is accelerated by the a-fluorine substitution. Based on a mechanistic study, a new reactivity of sulfoximine (as a radical monofluoromethylation reagent) is disclosed.
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