期刊
CHEMICAL SCIENCE
卷 5, 期 9, 页码 3634-3639出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc01013b
关键词
-
资金
- National Basic Research Program of China (973 Program) [2013CB836900]
- Area of Excellence Scheme of the University Grants Committee [AoE/M-12/06]
The 2-aminophosphonium iodide lactosamine glycoside (Lafont intermediate) readily obtained from lactose has been previously shown not to be amenable to derivatization for oligosaccharide synthesis, but has now been successfully converted via the salicylaldehyde imine into suitably protected lactosamine building blocks (13-16) for glycosylation. The titled strategy has enabled us to rapidly synthesize the Neu5Ac-alpha-2,3LacNAc-beta-1,3LacNAc pentasaccharide and Neu5Ac-alpha-2,3LacNAc-beta-1,3LacNAc-beta-1,3LacNAc heptasaccharide. Furthermore, this strategy has been adopted for the synthesis of other 2-amino sugars (e.g., 23-27), which provides a useful method for the preparation of 2-amino sugar building blocks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据