期刊
CHEMICAL SCIENCE
卷 4, 期 8, 页码 2995-3008出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc50862e
关键词
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资金
- European Commission
- Ministerio de Ciencia e Innovacion, Spain
Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.
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