期刊
CHEMICAL SCIENCE
卷 4, 期 10, 页码 3839-3844出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc51328a
关键词
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资金
- NSF [CHE-1153122]
- NIH [1DP2OD007246, 1R21EB013379]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1153122] Funding Source: National Science Foundation
Poly(arginine) mimics bearing long hydrophobic side chains adopt a stable helical conformation and exhibit helix-related cell-penetrating properties. Elongating the polypeptide backbone length and increasing side chain hydrophobicity further increase the helicities of poly(arginine) mimics. These helical poly(arginine) mimics show superior cell membrane permeability up to two orders of magnitude higher than that of HIV-TAT peptide and excellent DNA and siRNA delivery efficiencies in various mammalian cells.
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