4.8 Article

Helical poly(arginine) mimics with superior cell-penetrating and molecular transporting properties

期刊

CHEMICAL SCIENCE
卷 4, 期 10, 页码 3839-3844

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc51328a

关键词

-

资金

  1. NSF [CHE-1153122]
  2. NIH [1DP2OD007246, 1R21EB013379]
  3. Division Of Chemistry
  4. Direct For Mathematical & Physical Scien [1153122] Funding Source: National Science Foundation

向作者/读者索取更多资源

Poly(arginine) mimics bearing long hydrophobic side chains adopt a stable helical conformation and exhibit helix-related cell-penetrating properties. Elongating the polypeptide backbone length and increasing side chain hydrophobicity further increase the helicities of poly(arginine) mimics. These helical poly(arginine) mimics show superior cell membrane permeability up to two orders of magnitude higher than that of HIV-TAT peptide and excellent DNA and siRNA delivery efficiencies in various mammalian cells.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据