期刊
CHEMICAL SCIENCE
卷 4, 期 4, 页码 1876-1880出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc22051f
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资金
- Robert A. Welch Foundation [F-0038]
- NSF-ICC [CHE-1021640]
- NSF-DFG [BR 1646/6-1]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1021640] Funding Source: National Science Foundation
The regioselective reductive coupling of paraformaldehyde to 2-substituted dienes at positions C1, C2 and C3 was achieved using metal catalysts based on nickel, cationic ruthenium and neutral ruthenium, respectively. Whilst C1 adducts predominate using dienes, silicon- or tin-substituted dienes exhibit C4 regioselectivity - the first time that this regioselectivity has been observed for the coupling of 2-substituted butadienes to aldehydes. Both nickel- and ruthenium-catalyzed processes avoid pyrophoric or mass intensive reducing agents, using paraformaldehyde or isopropanol, respectively. These couplings may be viewed as alternatives to diene hydroformylation, for which regioselective formation of constitutionally isomeric products has not yet been achieved.
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