期刊
CHEMICAL SCIENCE
卷 4, 期 8, 页码 3160-3165出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc51209f
关键词
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资金
- University of North Carolina at Chapel Hill
- Packard Foundation
Herein is presented a direct method for the metal-free hydrotrifluoromethylation of alkenes. The method relies on the single electron oxidation of a commercially available sodium trifluoromethanesulfinate salt (CF3SO2Na, Langlois reagent) by N-Me-9-mesityl acridinium as a photoredox catalyst. Methyl thiosalicylate is used as a substoichiometric H-atom donor for aliphatic alkenes, and thiophenol is used as a stoichiometric H-atom donor for styrenyl substrates. The substrate scope for the transformation is broad, including mono-, di- and trisubstituted aliphatic and styrenyl alkenes, with high regioselectivity in nearly all cases examined.
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