期刊
CHEMICAL SCIENCE
卷 4, 期 12, 页码 4494-4498出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc51599k
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资金
- Netherlands Organization for Scientific Research (NWO)
- Dutch Technology Foundation (STW)
- NWO
We developed a scalable synthesis of gamma-thiolysine starting straight from lysine. The application of gamma-thiolysine was compared to delta-thiolysine in the chemical synthesis of K48 and K33 linked diubiquitin conjugates. Both gamma- and delta-thiolysine were found to perform equally efficiently as handles for nonenzymatic ubiquitination.
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