期刊
CHEMICAL SCIENCE
卷 4, 期 8, 页码 3118-3123出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc51080h
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资金
- Funding Program for Next Generation World-Leading Researchers (JSPS)
Direct substitution of hydrogen in C(sp(3))-H bonds by 4-pyridine was achieved by employing benzophenone and 4-cyanopyridine in aqueous acetonitrile under photo-irradiating conditions. This simple and mild 4-pyridination proceeds in a highly chemoselective manner especially at benzylic C(sp(3))-H bonds without affecting polar functional groups, and enables intermolecular formation of sterically hindered bonds between alkylaromatics and 4-pyridine. The present methodology thus serves as a powerful tool for construction of biologically active and functional molecules with 4-pyridine substructures.
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