4.8 Article

Metal-free oxidative tandem coupling of activated alkenes with carbonyl C(sp2)-H bonds and aryl C(sp2)-H bonds using TBHP

期刊

CHEMICAL SCIENCE
卷 4, 期 6, 页码 2690-2694

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc50810b

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资金

  1. Natural Science Foundation of China [21172060]
  2. Fundamental Research Funds for the Central Universities (Hunan University) [2011-015]
  3. Hunan Provincial Natural Science Foundation of China [13JJ2018]
  4. China Postdoctoral Science Foundation [2012M511716]

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A metal-free oxidative tandem coupling of activated alkenes with carbonyl C(sp(2))-H bonds and aryl C(sp(2))-H bonds using TBHP is established for the synthesis of 3-(2-oxoethyl)indolin-2-ones. This method allows 1,2-difunctionalization of the C-C double bond in N-arylacrylamides by simultaneous formation of two C(sp(2))-C(sp(3)) bonds.

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