期刊
CHEMICAL SCIENCE
卷 4, 期 8, 页码 3148-3153出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc50903f
关键词
-
资金
- EPSRC
- ERC [FCC266804]
A series of N-methyl-D-aspartate (NMDA) receptor-targeted MRI contrast agents has been developed, based on the known competitive NMDA antagonist, 3,4-diamino-3-cyclobutene-1,2-dione. Their use as responsive MR imaging probes has been evaluated in vitro and two contrast agents showed 170-176% enhancements in relaxation rate, following incubation with a neuronal cell line model. A derivative of the lead compound was prepared containing a biotin moiety, and both the specificity and reversibility of binding to the NMDA cell surface receptors demonstrated using confocal microscopy.
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