期刊
CHEMICAL SCIENCE
卷 3, 期 5, 页码 1640-1644出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sc00663d
关键词
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资金
- NSERC
- CIHR
- CHRP
- Dalhousie University
Growth of Streptomyces venezuelae ISP5230 with O-propargyl-L-serine led to the efficient production of an alkyne-containing jadomycin. The installed alkyne functionality provided a uniquely reactive handle within the natural product and was subsequently reacted with a series of azides to afford an eight-member library of jadomycin triazoles. The compounds were evaluated for their DNA cleavage, antibacterial and cytotoxic properties.
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