期刊
CHEMICAL SCIENCE
卷 3, 期 7, 页码 2383-2387出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sc00027j
关键词
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资金
- Spanish grants [SAF2010-20822-C02, CTQ2009-14431/BQU]
- Consolider Ingenio [CSD2007-00006]
- Xunta de Galicia [INCITE09 209 084PR, GRC2010/12, PGIDIT08CSA-047209PR]
- Spanish MEC
Bisbenzamidines are an important family of minor groove DNA-binding agents. We present a one-step synthesis of aromatic aza-bisbenzamidines that allows straightforward and versatile access to a large number of these molecules. One of them, the azide-aza-bisbenzamidine 13, can be readily modified via click-chemistry with a variety of functionalities that can, therefore, be delivered to the vicinity of an A/T-rich DNA minor groove. This strategy, therefore, provides a simple means for triggering site selective, DNA-promoted biochemical and physicochemical processes.
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