相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。A flow-based synthesis of Imatinib: the API of Gleevec
Mark D. Hopkin et al.
CHEMICAL COMMUNICATIONS (2010)
Switching the Chemoselectivity in the Amination of 4-Chloroquinazolines with Aminopyrazoles
Zhenlu Shen et al.
ORGANIC LETTERS (2010)
Recent Applications of Palladium-Catalyzed Coupling Reactions in the Pharmaceutical, Agrochemical, and Fine Chemical Industries
Christian Torborg et al.
ADVANCED SYNTHESIS & CATALYSIS (2009)
Triarylamine: a promising core unit for efficient photovoltaic materials
Zhijun Ning et al.
CHEMICAL COMMUNICATIONS (2009)
An Efficient Process for Pd-Catalyzed C-N Cross-Coupling Reactions of Aryl Iodides: Insight Into Controlling Factors
Brett P. Fors et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Synthesis of imatinib: a convergent approach revisited
Andrey S. Ivanov et al.
MONATSHEFTE FUR CHEMIE (2009)
An improved synthesis of N-aryl and N-heteroaryl substituted homopiperazines-from conventional thermal conditions to scaling-up using microwave heating
Uwe Schoen et al.
TETRAHEDRON (2009)
Evolution of a Fourth Generation Catalyst for the Amination and Thioetherification of Aryl Halides
John F. Hartwig
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Copper/Amino Acid Catalyzed Cross-Couplings of Aryl and Vinyl Halides with Nucleophiles
Dawei Ma et al.
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Well-Defined N-Heterocyclic Carbenes-Palladium(II) Precatalysts for Cross-Coupling Reactions
Nicolas Marion et al.
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Discovery of selective aminothiazole aurora kinase inhibitors
Carsten B. Andersen et al.
ACS CHEMICAL BIOLOGY (2008)
Biaryl phosphane ligands in palladium-catalyzed amination
David S. Surry et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Development of CXCR3 antagonists. Part 4: Discovery of 2-amino-(4-tropinyl)quinolines
Roland L. Knight et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors
David Bauer et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Discovery of piperidine carboxamide TRPV1 antagonists
Wing S. Cheung et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Hole-transporting hydrazones
Ramunas Lygaitis et al.
CHEMICAL SOCIETY REVIEWS (2008)
A highly active catalyst for Pd-catalyzed amination reactions: Cross-coupling reactions using aryl mesylates and the highly selective monoarylation of primary amines using aryl chlorides
Brett P. Fors et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Highly reactive, general and long-lived catalysts for palladium-catalyzed amination of heteroaryl and aryl chlorides, bromides, and iodides: Scope and structure-activity relationships
Qilong Shen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
A new class of easily activated palladium precatalysts for facile C-N cross-coupling reactions and the low temperature oxidative addition of aryl chlorides
Mark R. Biscoe et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Synthesis of End-Functionalized Polyanilines
Rienk Eelkema et al.
MACROMOLECULES (2008)
[(CyPF-tBu)PdCl2]:: An air-stable, one-component, highly efficient catalyst for amination of heteroaryl and aryl halides
Qilong Shen et al.
ORGANIC LETTERS (2008)
A facile total synthesis of imatinib base and its analogues
Yi-Feng liu et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2008)
N-Heterocyclic Carbenes (NHCs) Containing N-C-Palladacycle Complexes: Synthesis and Reactivity in Aryl Amination Reactions
Julie Broggi et al.
ORGANOMETALLICS (2008)
Optimization of the conditions for copper-mediated N-arylation of heteroarylamines
Yifeng Liu et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2007)
Applicability aspects of transition metal-catalyzed aromatic Amination Protocols in medicinal chemistry
Stefan Tasler et al.
ADVANCED SYNTHESIS & CATALYSIS (2007)
Flying under the radar:: the new wave of BCR-ABL inhibitors
Alfonso Quintas-Cardama et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Palladium-catalyzed couplings of heteroaryl amines with aryl halides using sodium phenolate as the stoichiometric base
James P. Schulte et al.
SYNLETT (2007)
Lewis acid acceleration of C-N bond-forming reductive elimination from heteroarylpalladium complexes and catalytic amidation of heteroaryl bromides
Qilong Shen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Discovery and characterization of 4′-(2-Furyl)-N-pyridin-3-yl-4,5′-bipyrimidin-2′-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist
Bernat Vidal et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug
Francesco Leonetti et al.
TETRAHEDRON LETTERS (2007)
Selective palladium-catalyzed amination of the heterocyclic core of variolins
Alejandro Baeza et al.
TETRAHEDRON LETTERS (2007)
Palladium complexes of N-heterocyclic carbenes as catalysts for cross-coupling reactions - A synthetic chemist's perspective
Eric Assen B. Kantchev et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Process chemistry: The science, business, logic, and logistics
Tony Y. Zhang
CHEMICAL REVIEWS (2006)
Bulky alkylphosphines with neopentyl substituents as ligands in the amination of aryl bromides and chlorides
Lensey L. Hill et al.
JOURNAL OF ORGANIC CHEMISTRY (2006)
Rapid room temperature Buchwald-Hartwig and Suzuki-Miyaura couplings of heteroaromatic compounds employing low catalyst loadings
Oscar Navarro et al.
CHEMISTRY-A EUROPEAN JOURNAL (2006)
Synthesis of the PhIP adduct of 2′-deoxyguanosine and its incorporation into oligomeric DNA
Radha Bonala et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2006)
Air- and moisture-stable secondary phosphine oxides as preligands in catalysis
Lutz Ackermann
SYNTHESIS-STUTTGART (2006)
(IPr)Pd(acac)Cl: An easily synthesized, efficient, and versatile precatalyst for C-N and C-C bond formation
N Marion et al.
JOURNAL OF ORGANIC CHEMISTRY (2006)
Modified (NHC)Pd(allyl)Cl (NHC = N-heterocyclic carbene) complexes for room-temperature Suzuki-Miyaura and Buchwald-Hartwig reactions
N Marion et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
A very concise synthesis of a potent N-(1,3-thiazol-2-yl)pyridin-2-amine KDR kinase inhibitor
M Zhao et al.
TETRAHEDRON (2006)
Monodentate phosphines provide highly active catalysts for Pd-catalyzed C-N bond-forming reactions of heteroaromatic halides/amines and (H)N-heterocycles
Kevin W. Anderson et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Industrial-scale palladium-catalyzed coupling of aryl halides and amines - A personal account
SL Buchwald et al.
ADVANCED SYNTHESIS & CATALYSIS (2006)
Role of tyrosine kinase inhibitors in cancer therapy
A Arora et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Efficient palladium catalysts for the amination of aryl chlorides: a comparative study on the use of phosphium salts as precursors to bulky, electron-rich phosphines
A Tewari et al.
TETRAHEDRON (2005)
Amino acid promoted CuI-catalyzed C-N bond formation between aryl halides and amines or N-containing heterocycles
H Zhang et al.
JOURNAL OF ORGANIC CHEMISTRY (2005)
Copper-catalyzed aryl amination in aqueous media with 2-dimethylaminoethanol ligand
Z Lu et al.
TETRAHEDRON LETTERS (2005)
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
M Deininger et al.
BLOOD (2005)
Highly reactive, general, and long-lived catalysts for coupling heteroaryl and aryl chlorides with primary nitrogen nucleophiles
QL Shen et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Efficient Pd-catalyzed amination of heteroaryl halides
MD Charles et al.
ORGANIC LETTERS (2005)
A short and efficient synthesis of N-aryl- and N-heteroaryl-N′-(arylalkyl)piperazines
D Michalik et al.
TETRAHEDRON LETTERS (2004)
Palladium-catalysed amination of electron-deficient or relatively electron-rich benzo[b]thienyl bromides -: Preliminary studies of antimicrobial activity and SARs
MJRP Queiroz et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2004)
Synthesis of C2-symmetric and unsymmetrically substituted 2,2′-dipyridylamines and crystal structure of a chiral 2,2′-dipyridylamine copper(II) complex
C Bolm et al.
JOURNAL OF ORGANOMETALLIC CHEMISTRY (2004)
New ligands for a general palladium-catalyzed amination of aryl and heteroaryl chlorides
F Rataboul et al.
CHEMISTRY-A EUROPEAN JOURNAL (2004)
Application of a new bicyclic triaminophosphine ligand in Pd-catalyzed Buchwald-Hartwig amination reactions of aryl chlorides, bromides, and iodides
S Urgaonkar et al.
JOURNAL OF ORGANIC CHEMISTRY (2003)
Understanding the coupling of heteroaromatic substrates: Synthesis, structures, and reductive eliminations of heteroarylpalladium amido complexes
MW Hooper et al.
ORGANOMETALLICS (2003)
Scope and mechanism of palladium-catalyzed amination of five-membered heterocyclic halides
MW Hooper et al.
JOURNAL OF ORGANIC CHEMISTRY (2003)
The combinatorial synthesis of bicyclic privileged structures or privileged substructures
DA Horton et al.
CHEMICAL REVIEWS (2003)
Pd-catalyzed N-arylation of heteroarylamines
JJ Yin et al.
ORGANIC LETTERS (2002)
Improved functional group compatibility in the palladium-catalyzed synthesis of aryl amines
MC Harris et al.
ORGANIC LETTERS (2002)
Air stable, sterically hindered ferrocenyl dialkylphosphines for palladium-catalyzed C-C, C-N, and C-O bond-forming cross-couplings
N Kataoka et al.
JOURNAL OF ORGANIC CHEMISTRY (2002)
Glivec (ST1571, Imatinib), a rationally developed, targeted anticancer drug
R Capdeville et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
A new improved catalyst for the palladium-catalyzed amination of aryl chlorides
A Ehrentraut et al.
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL (2002)
Mono N-arylation of piperazine(III):: metal-catalyzed N-arylation and its application to the novel preparations of the antifungal posaconazole and its advanced intermediate
M Hepperle et al.
TETRAHEDRON LETTERS (2002)
Synthesis of secondary and tertiary aminothiophenes via palladium-catalyzed amination
K Ogawa et al.
JOURNAL OF ORGANIC CHEMISTRY (2001)
Synthesis of C8-adenosine adducts of arylamines using palladium catalysis
E Schoffers et al.
ORGANIC LETTERS (2001)
Synthesis of the C8-deoxyguanosine adduct of the food mutagen IQ
ZW Wang et al.
ORGANIC LETTERS (2001)