期刊
CHEMICAL SCIENCE
卷 2, 期 4, 页码 760-764出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0sc00620c
关键词
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资金
- NIH [R00 GM82983]
- Pew Biomedical Scholar Award
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R00GM082983] Funding Source: NIH RePORTER
Natural products account for a significant proportion of modern day therapeutic agents. However, the discovery of novel compounds is hindered by the isolation process, which often relies upon extraction and chromatographic separation techniques. These methods, which are dependent upon the physicochemical properties of the compounds, have a limited ability to both purify and concentrate the minor components of a biological extract. We have devised an isolation strategy based upon an orthogonal chemical feature, namely, functional group composition. Development of a functional group-targeted method is expected to achieve exceptional resolution given the large number of distinct moieties present in natural product extracts. Here, we describe the generation of controllably reversible covalent enrichment tags for the chemoselective isolation of alcohol-containing natural products from complex mixtures.
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