期刊
CHEMICAL SCIENCE
卷 2, 期 10, 页码 1910-1917出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1sc00301a
关键词
-
资金
- National Institutes of Health [GM067201]
- Croucher Foundation
- Swiss National Science Foundation
We describe a new molecular design for sensing toxic gases in air that employs DNA-polyfluorophores as reporters. In these polyfluorophores (ODFs), the DNA backbone is used as a scaffold to arrange several fluorescent aromatic hydrocarbons/heterocycles as DNA base replacements in a photophysically interacting stack. A library of 256 different tetramer ODFs was constructed on PEG-polystyrene beads and tested for optical responses to a set of toxic gases, SO2, H2S, MeSH, NH3, NHMe2, HCl, Cl-2, and BF3. A set of 15 responding sequences was resynthesized, characterized, and cross-screened under a microscope against all eight gases at 1000 ppm. Responses were measured by changes in fluorescence wavelength and intensity, which were quantified as Delta(R, G, B, L) data from bead images. The data show a large range of responses, including lighting up, quenching, and color changes; remarkably, some single sensors showed all three types of responses to the varied analytes. Statistical methods were used to identify small sets of only three chemosensors that could be used to distinguish all eight analytes. The results establish that ODFs on surfaces can bind and report on small, simple gas molecules with highly varied responses. The DNA-like structure of the sensor molecules confers a number of potential advantages including simple synthesis, high diversity, and rapid sensor discovery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据