期刊
CHEMICAL SCIENCE
卷 2, 期 3, 页码 544-551出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0sc00498g
关键词
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资金
- University of Toronto
- Canada Foundation for Innovation
- Ontario Research Fund
- Boehringer Ingelheim Ltd. Canada
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Alfred P. Sloan Fellowship
- NSERC
- Canada Graduate Scholarship
We report a novel strategy for the formal activation of sp(3) C-O bonds under Ru catalysis. In this reaction, an O-alkylpyridine undergoes migratory rearrangement to its corresponding N-alkylpyridone via coordination of the Lewis basic N atom. This transformation represents the first general catalytic approach to O- to N-alkyl migration in N-containing heterocycles. Extension of this methodology to other heterocycles, including O-alkylpyridazines and O-alkylazoles, was achieved.
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