期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 3, 期 8, 页码 1624-1632出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb01702a
关键词
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资金
- National Natural Science Foundation of China [21175061, 21375050, 21405063]
- Natural Science Foundation of Jiangsu province [BK20130481]
- Priority Academic Program Development of Jiangsu Higher Education Institutions [PAPD-2014-37]
- Scientific Research Foundation of Jiangsu University [12JDG087]
- Key Laboratory of Modern Agriculture Equipment and Technology [NZ201109, NZ201307]
In this study, multiwalled carbon nanotube@reduced graphene oxide nanoribbon (MWCNT@rGONR) core-shell heterostructures have been synthesized by the facile unzipping of MWCNTs and subsequent chemical reduction with hydrazine. MWCNTs with diameter <10 nm were selected as the starting material to maintain narrow ribbons <30 nm wide with a few-layer structure. The most important discovery is that the resulting MWCNT@rGONR heterostructures possess intrinsic peroxidase-like activity, 15.9 times higher than that of MWCNTs and 8.4 times higher than that of their unreduced form. The nature of the peroxidase-like activity of the MWCNT@rGONR heterostructures can be attributed to the acceleration of their electron-transfer process and the consequent facilitation of (OH)-O-center dot radical generation. Kinetic analysis demonstrates that the catalytic behavior is in accordance with typical Michaelis-Menten kinetics and the obtained kinetic parameters indicate that the MWCNT@rGONR heterostructures display a higher affinity for both H2O2 and 3,3,5,5-tetramethylbenzidine than that of horseradish peroxidase. On this basis, we have employed the MWCNT@rGONR heterostructures as novel biosensing platforms to develop a simple, sensitive, and selective colorimetric biosensor for free cholesterol determination. This work will facilitate the formation of MWCNT@rGONR heterostructures with narrow ribbons and the utilization of their intrinsic peroxidase-like activity in biotechnology and medical diagnostics.
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