期刊
CHEMICAL SCIENCE
卷 2, 期 4, 页码 690-695出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0sc00564a
关键词
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资金
- J. Evans-Attwell-Welch Post-Doctoral Fellowship
- Robert A. Welch Foundation [C-1680]
- Rice University
Coiled-coil assembly of substrate peptides with dirhodium metallopeptide catalysts enables side-chain modification on the basis of molecular shape. A wide range of amino acids are effectively modified, including the first examples of carboxamide (glutamine and asparagine) modification. The method is used to achieve covalent modification of the c-Fos bZip domain at different residues, depending on the metallopeptide structure. By combining promiscuous catalytic reactivity with specific molecular recognition, this work establishes a general strategy for protein modification on the basis of molecular shape. A broad range of peptide-protein interactions are potentially amenable to this approach.
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