期刊
JOURNAL OF BREATH RESEARCH
卷 8, 期 3, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1752-7155/8/3/037108
关键词
SIFT-MS; breath analysis; portable breath analyser
资金
- Juvenile Diabetes Research Foundation (JDRF) [5-2007-237]
- Evelyn Trust
- Wellcome Trust
- Cambridge NIHR Biomedical Research Centre
Monitoring blood glucose concentrations is a necessary but tedious task for people suffering from diabetes. It has been noted that breath in people suffering with diabetes has a different odour and thus it may be possible to use breath analysis to monitor the blood glucose concentration. Here, we evaluate the analysis of breath using a portable device containing a single mixed metal oxide sensor during hypoglycaemic glucose clamps and compare that with the use of SIFT-MS described in previously published work on the same set of patients. Outputs from both devices have been correlated with the concentration of blood glucose in eight volunteers suffering from type 1 diabetes mellitus. The results demonstrate that acetone as measured by SIFT-MS and the sensor output from the breath sensing device both correlate linearly with blood glucose; however, the sensor response and acetone concentrations differ greatly between patients with the same blood glucose. It is therefore unlikely that breath analysis can entirely replace blood glucose testing.
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