期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 3, 期 31, 页码 6456-6461出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb00797f
关键词
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资金
- ANR P2N Mechanano
- PUF program [20091853]
- Conseil Regional d'Aquitaine (CRA)
- CRA
We report a two-photon-actuated cancer cell killing system that kills the cancer cells via drug delivery through multifunctional mesoporous silica nanogates. Two-photon-sensitive mesoporous organosilica (M2PS) nanocarriers were synthesized via the co-condensation of a silica precursor and a two-photon electron donor. The nanogates were constructed using a fast one-pot process at room temperature on the drug-loaded M2PS nanoparticles (NPs) with the bis(3-triethoxysilylpropyl) disulfide precursor. One and two-photon-actuated cargo releases from the M2PS nanogates were successfully monitored in aqueous solutions. Furthermore, the cellular uptake in MCF-7 cells was demonstrated via two-photon fluorescence imaging of the NPs, which were then applied successfully for drug delivery in cells.
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