期刊
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
卷 7, 期 4, 页码 321-324出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1995-7645(14)60048-1
关键词
Bone mesenchymal stem cells; Hepatic fibrosis rats; Smadv
资金
- Guangxi Scientific and Technological Project [11107009-3-1]
- Guangxi Natural Science Fund Projects [2010 GXNSFA013211]
Objective: To investigate the impact of bone marrow mesenchymal stem cells on Smad expression of hepatic fibrosis rats. Methods: A total of 48 adult female SD rats were randomly divided into three groups, normal control group (n=10), observation group (n=19) with liver fibrosis model rats injected with BMSCs cells; model group (n=19), with liver fibrosis model rats injected with physiological saline. Serum index, TGF-beta 1 and Smad expression were detected. Results: Type III procollagen, IV collagen, hyaluronic acid, laminin levels of observation group were significantly lower than those of model group (P<0.05). The content and expression of TGF-beta 1 in serum and liver tissue of observation group were significantly lower than those of model group(P<0.05). Compared with normal control group, the Smad3, Smad4 mRNA and protein expression of model group were significantly increased, the Smad7 mRNA and protein expression were significantly reduced (P<0.05). Compared with model group, Smad3, Smad4 mRNA and protein expression of observation group were significantly reduced, and Smad7 mRNA expression were significantly increased (P<0.05). Conclusions: BMSCs can regulate Smad expression to some extent, and reduce the degree of liver fibrosis.
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