期刊
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
卷 7, 期 6, 页码 483-487出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1995-7645(14)60079-1
关键词
XRCC3; THr241Met; Meta analysis; Lung cancer susceptibility; Populations in East Asia
Objective: To assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia. Methods: Related studies of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia were collected through searching the Pubmed, Embase Library, SPRINGER, CNKI and CSSCI. Results: According to the entry criteria, there were 8 case-control studies in the assessing 5),stem and there were 6 321 study cases, including 3 215 patients with lung cancer and 3 106 cases without cancers. Meta analysis results showed the combined OR value of the ratio of genotype Thr/Met+Met/Met and Thr/Thr was 1.03 (95%CI: 0.89-1.20) (P > 0.05). Conclusions: XRCC3 Thr241Met polymorphism may not related to lung cancer susceptibility of populations in East Asia. Allele 241Met did not increase the risk of lung cancer.
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