期刊
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
卷 5, 期 3, 页码 202-209出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.1016/S1995-7645(12)60025-X
关键词
Antimicrobial; Gas chromatography-mass spectrometry; Essential oil; Curcuma aeruginosa; Curcuma mangga; Zingiber cassumunar
资金
- Kulliyyah of Science, International Islamic University Malaysia
Objective: To analyze the chemical composition of the essential oils of Curcuma aeruginosa (C. aeruginosa). Curcuma mangga (C. mangga). and Zingiber cassumunar (Z. cassumunar), and study their antimicrobial activity. Methods: Essential oils obtained by steam distillation were analyzed by gas chromatography-mass spectrometry (CC-MS). The antimicrobial activity of the essential oils was evaluated against four bacteria: Bacillus cereus (B. (welts). Staplolococcus (wrens (S. aureus), Escherichia coli (E. colt), and Pseudomonas aeruginosa (P. aeruginosa); and two fungi: Candida albicans (C. albicans) and Cyptococcus neoformans (C. neoformans), using disc-diffusion and broth microdilution methods. Results: Cycloisolongifolene. 8.9-dehydro-9-formyl (35.29%) and dihydrocostunolide (22.51%) were the major compounds in C. aeruginosa oil; whereas caryophyllene oxide (18.71%) and caryophyllene (12.69%) were the major compounds in C. mangga oil: and 2.6,9,9-tetramethyl-2.6.10-cycloundecatrien-1-one (60.77%) and alpha -caryophyllene (23.92%) were abundant in Z. cassumunar oil. The essential oils displayed varying degrees of antimicrobial activity against all tested microorganisms. C. mangga oil had the highest and most broad-spectrum activity by inhibiting all microorganisms tested, with C. neoformans being the most sensitive microorganism by having the lowest minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of 0.1 mu L/mL. C. aeruginosa oil showed mild antimicrobial activity. whereas Z. cassumunar had very low or weak activity against the tested microorganisms. Conclusion: The preliminary results suggest promising antimicrobial properties of C. mangga and C. aeruginosa, which may be useful for food preservation; pharmaceutical treatment and natural therapies.
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