期刊
ARTHRITIS CARE & RESEARCH
卷 63, 期 6, 页码 821-826出版社
WILEY-BLACKWELL
DOI: 10.1002/acr.20449
关键词
-
类别
资金
- Eli Lilly
- Boehringer Ingelheim GmbH
- Lilly
- AstraZeneca
- Bial
- Essex
- Jazz Pharmaceuticals
- Pfizer
- Pierre Fabre
- UCB
- Forest
- Cypress Biosciences
- Merck
- Boehringer Ingelheim
- Forest Laboratories
- Theravance
- Allergen
- Takeda
- Sanofi Aventis
Objective. To estimate the minimum clinically important difference (MCID) for several pain measures obtained from the Brief Pain Inventory (BPI) for patients with fibromyalgia. Methods. Data were pooled across 12-week treatment periods from 4 randomized, double-blind, placebo-controlled studies designed to evaluate the safety and efficacy of duloxetine for the treatment of fibromyalgia. Each study enrolled subjects with American College of Rheumatology defined fibromyalgia who presented with moderate to severe pain. The MCIDs for the BPI average pain item score and the BPI severity score (the mean of the BPI pain scale values: right now, average, least, and worst) were estimated by anchoring against the Patient's Global Impressions of Improvement scale. Results. The anchor-based MCIDs for the BPI average pain item and severity scores were 2.1 and 2.2 points, respectively. These MCIDs correspond to 32.3% and 34.2% reductions from baseline in scores. Conclusion. In these analyses, the MCIDs for several pain measures obtained from the BPI were similar (similar to 2 points) and corresponded to a 30-35% improvement from baseline to end point. These findings may be beneficial for use in designing clinical trials in which the BPI is used to evaluate improvements in pain severity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据