期刊
TICKS AND TICK-BORNE DISEASES
卷 1, 期 1, 页码 66-68出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ttbdis.2010.01.001
关键词
Francisella; Tularemia; Dog tick; Dermacentor; Quantum of infection
资金
- National Institutes of Health [R01 AI 064218]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI064218] Funding Source: NIH RePORTER
The American dog tick Dermacentor variabilis is fundamental to the perpetuation of Francisella tularensis tularensis on Martha s Vineyard Massachusetts U S A Although Infected ticks are relatively common on the island human cases deriving from tick bite are rare It may be that the quantum of bacteria within these naturally Infected ticks is frequently too small to cause disease Accordingly we quantified the amount of F t tularensis bacteria in host-seeking ticks from the Island Contrary to our expectations the majority of the ticks harbor large numbers of bacteria (median 3 3 x 10(8) genome equivalents/tick) Such a large quantum of infection might suggest that aerosolization of the ticks themselves might comprise the proximal determinant of risk for the inhalational tularemia that is common on Martha s Vineyard However the paradox of fewer ulceroglandular tularemia cases than would be expected given the abundance of potentially highly infectious ticks remains to be solved (C) 2010 Elsevier GmbH All rights reserved
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