期刊
VIRUSES-BASEL
卷 10, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/v10090451
关键词
Orthobunyavirus; Cat Que virus; Manzanilla virus; pathogen discovery
类别
资金
- Viral Special Pathogens Branch, The Centers for Disease Control and Prevention, Atlanta, GA, USA
- National Institutes of Virology, Pune, India
Next-generation sequencing (NGS) of agents causing idiopathic human diseases has been crucial in the identification of novel viruses. This study describes the isolation and characterization of two novel orthobunyaviruses obtained from a jungle myna and a paddy bird from Karnataka State, India. Using an NGS approach, these isolates were classified as Cat Que and Balagodu viruses belonging to the Manzanilla clade of the Simbu serogroup. Closely related viruses in the Manzanilla clade have been isolated from mosquitos, humans, birds, and pigs across a wide geographic region. Since Orthobunyaviruses exhibit high reassortment frequency and can cause acute, self-limiting febrile illness, these data suggest that human and livestock infections of the Oya/CatQue/Manzanilla virus may be more widespread and/or under-reported than anticipated. It therefore becomes imperative to identify novel and unknown viruses in order to understand their role in human and animal pathogenesis. The current study is a step forward in this regard and would act as a prototype method for isolation, identification and detection of several other emerging viruses.
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