期刊
VIRUSES-BASEL
卷 6, 期 4, 页码 1759-1788出版社
MDPI
DOI: 10.3390/v6041759
关键词
Marburg; Lloviu; Ebola; emerging infectious diseases; Filovirus; disease ecology; review; Ravn; Chiroptera; bats
类别
资金
- United States Agency for International Development (USAID) Emerging Pandemic Threats PREDICT program [GHN-AOO-09-00010-00]
- NIAID Non-Biodefense Emerging Infectious Disease Research Opportunities award [R01 AI079231]
- David H. Smith Fellowship from the Cedar Tree Foundation
- Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Science and Technology Directorate, Department of Homeland Security and Fogarty International Center, National Institutes of Health
Filoviruses, including Ebolavirus and Marburgvirus, pose significant threats to public health and species conservation by causing hemorrhagic fever outbreaks with high mortality rates. Since the first outbreak in 1967, their origins, natural history, and ecology remained elusive until recent studies linked them through molecular, serological, and virological studies to bats. We review the ecology, epidemiology, and natural history of these systems, drawing on examples from other bat-borne zoonoses, and highlight key areas for future research. We compare and contrast results from ecological and virological studies of bats and filoviruses with those of other systems. We also highlight how advanced methods, such as more recent serological assays, can be interlinked with flexible statistical methods and experimental studies to inform the field studies necessary to understand filovirus persistence in wildlife populations and cross-species transmission leading to outbreaks. We highlight the need for a more unified, global surveillance strategy for filoviruses in wildlife, and advocate for more integrated, multi-disciplinary approaches to understand dynamics in bat populations to ultimately mitigate or prevent potentially devastating disease outbreaks.
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