期刊
VIRUSES-BASEL
卷 6, 期 12, 页码 4999-5027出版社
MDPI
DOI: 10.3390/v6124999
关键词
interferon induction; TLR; RLR; viral antagonism
类别
资金
- University of Maryland
- NIH [1R21AI068881]
- Natural Science Foundation of China [812721]
- China Scholarship Council
Interferons are a group of small proteins that play key roles in host antiviral innate immunity. Their induction mainly relies on host pattern recognition receptors (PRR). Host PRR for RNA viruses include Toll-like receptors (TLR) and retinoic acid-inducible gene I (RIG-I) like receptors (RLR). Activation of both TLR and RLR pathways can eventually lead to the secretion of type I IFNs, which can modulate both innate and adaptive immune responses against viral pathogens. Because of the important roles of interferons, viruses have evolved multiple strategies to evade host TLR and RLR mediated signaling. This review focuses on the mechanisms of interferon induction and antagonism of the antiviral strategy by RNA viruses.
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