期刊
VIRUSES-BASEL
卷 6, 期 11, 页码 4294-4313出版社
MDPI
DOI: 10.3390/v6114294
关键词
mosquito; Aedes; Culex; arbovirus; innate immunity; microbiota
类别
资金
- National Institutes of Health/National Institute of Allergy and Infectious Disease [R21AI090188, R01AI101431]
- Royal Thai Government
Diseases caused by arthropod-borne viruses (arboviruses), such as Dengue, West Nile, and Chikungunya, constitute a major global health burden and are increasing in incidence and geographic range. The natural microbiota of insect vectors influences various aspects of host biology, such as nutrition, reproduction, metabolism, and immunity, and recent studies have highlighted the ability of insect-associated bacteria to reduce vector competence for arboviruses and other pathogens. This reduction can occur through mechanisms, such as immune response activation, resource competition, or the production of anti-viral molecules. Studying the interactions between insect vectors and their microbiota is an important step toward developing alternative strategies for arbovirus transmission control.
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