期刊
VIRUSES-BASEL
卷 7, 期 1, 页码 27-36出版社
MDPI
DOI: 10.3390/v7010027
关键词
rabbit hemorrhagic disease virus (RHDV); rabbit hemorrhagic disease (RHD); new variant RHDV; genogroup 1; replacement; Portugal
类别
资金
- National Funds through FCT-Foundation for Science and Technology [FCT-ANR/BIA-BIC/0043/2012]
- FCT [SFRH/BD/78738/2011, IF/01396/2013]
- North Portugal Regional Operational Programme, under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF) [ON.2-O Novo Norte]
The Lagovirus rabbit hemorrhagic disease virus (RHDV), a member of the family Caliciviridae, severely affects European rabbit (Oryctolagus cuniculus) populations by causing rabbit hemorrhagic disease (RHD). RHDV is subdivided in six genogroups but, more recently, a new RHDV variant with a unique genetic and antigenic profile emerged. We performed a study in rabbits found dead in the field during 2013 and 2014 in Portugal to determine the prevalence of this new variant versus the classical RHDV. Fifty-seven liver samples were screened for the presence of RHDV and positive samples were genotyped. All cases of RHDV infection were caused by the new variant. The only former genogroup circulating in Portugal, G1, was not detected. We hence conclude that the new RHDV variant is replacing G1 in Portugal, probably due to a selective advantage. This sudden and rapid replacement emphasizes the necessity of continued monitoring of wild rabbit populations.
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