期刊
VIRUSES-BASEL
卷 5, 期 10, 页码 2329-2348出版社
MDPI
DOI: 10.3390/v5102329
关键词
West Nile virus; state of the art laboratory diagnostic; external quality assurance
类别
资金
- Fondi Finalizzati Lab P3 from Regione Emilia Romagna
- Italian Ministry of Health
- Project PREDEMICS (7th Framework Programme) [278433]
- European Centre for Disease Prevention and Control (ECDC) [ECDC/2008/011]
- Natural Environment Research Council [ceh010010] Funding Source: researchfish
West Nile virus, genus Flavivirus, is transmitted between birds and occasionally other animals by ornithophilic mosquitoes. This virus also infects humans causing asymptomatic infections in about 85% of cases and <1% of clinical cases progress to severe neuroinvasive disease. The virus also presents a threat since most infections remain unapparent. However, the virus contained in blood and organs from asymptomatically infected donors can be transmitted to recipients of these infectious tissues. This paper reviews the presently available methods to achieve the laboratory diagnosis of West Nile virus infections in humans, discussing the most prominent advantages and disadvantages of each in light of the results obtained during four different External Quality Assessment studies carried out by the European Network for Imported' Viral Diseases (ENIVD).
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