期刊
VIRUSES-BASEL
卷 6, 期 1, 页码 1-12出版社
MDPI
DOI: 10.3390/v6010001
关键词
hematopoietic stem cell; HIV; gene therapy; CCR5; engineered immunity
类别
资金
- NIH [R01 AI078806]
- California HIV/AIDS Research Program
- UCLA CFAR [5P30 AI028697]
Despite the enormous success of combined anti-retroviral therapy, HIV infection is still a lifelong disease and continues to spread rapidly worldwide. There is a pressing need to develop a treatment that will cure HIV infection. Recent progress in stem cell manipulation and advancements in humanized mouse models have allowed rapid developments of gene therapy for HIV treatment. In this review, we will discuss two aspects of HIV gene therapy using human hematopoietic stem cells. The first is to generate immune systems resistant to HIV infection while the second strategy involves enhancing anti-HIV immunity to eliminate HIV infected cells.
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