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Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle

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VIRUSES-BASEL
卷 5, 期 6, 页码 1374-1394

出版社

MDPI
DOI: 10.3390/v5061374

关键词

Brd4; BET protein; HPV; papillomavirus; transcription; chromatin; replication; tethering; partitioning; bromodomain

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  1. Intramural Research Program of the NIAID
  2. NIH

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The Brd4 protein is an epigenetic reader that is central to regulation of cellular transcription and mitotic bookmarking. The transcription and replication proteins of many viruses interact with Brd4. We describe the multiple roles of Brd4 in the papillomavirus lifecycle.

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