期刊
VIRUSES-BASEL
卷 5, 期 8, 页码 1934-1947出版社
MDPI
DOI: 10.3390/v5081934
关键词
small ruminant lentivirus; maedi-visna virus; APOBEC3; Vif; restriction factors; host defence
类别
资金
- Icelandic Research Fund
- University of Iceland Research Fund
It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that block retroviral infection. These inhibitors are counteracted by the Vif proteins encoded by most lentiviruses. In this paper, we will review the interaction of the lentiviral Vif proteins with the APOBEC3 proteins, with an emphasis on sheep APOBEC3 and maedi-visna virus (MVV) Vif.
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