期刊
VIRUSES-BASEL
卷 4, 期 3, 页码 363-382出版社
MDPI
DOI: 10.3390/v4030363
关键词
envelope protein; coronavirus assembly; ion channel; Golgi complex; membrane protein topology
类别
资金
- NIH
- Isaac Morris and Lucille Elizabeth Hay Graduate Fellowship
The coronavirus E protein is a small membrane protein that has an important role in the assembly of virions. Recent studies have indicated that the E protein has functions during infection beyond assembly, including in virus egress and in the host stress response. Additionally, the E protein has ion channel activity, interacts with host proteins, and may have multiple membrane topologies. The goal of this review is to highlight the properties and functions of the E protein, and speculate on how they may be related.
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