期刊
VIRUSES-BASEL
卷 4, 期 8, 页码 1335-1353出版社
MDPI
DOI: 10.3390/v4081335
关键词
herpes viruses; MHC class II; CD4 T cell; immune evasion
类别
资金
- Medical Research Council UK, London [G0901755]
- MRC [G0901755] Funding Source: UKRI
- Medical Research Council [G0901755, G9818340B] Funding Source: researchfish
Lifelong persistent infection by herpesviruses depends on the balance between host immune responses and viral immune evasion. CD4 T cells responding to antigens presented on major histocompatibility complex class II (MHC-II) molecules are known to play an important role in controlling herpesvirus infections. Here we review, with emphasis on human herpesvirus infections, the strategies evolved to evade CD4 T cell immunity. These viruses target multiple points on the MHC class II antigen presentation pathway. The mechanisms include: suppression of CIITA to inhibit the synthesis of MHC class II molecules, diversion or degradation of HLA-DR molecules during membrane transport, and direct targeting of the invariant chain chaperone of HLA-DR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据