期刊
VIRUSES-BASEL
卷 3, 期 6, 页码 677-713出版社
MDPI AG
DOI: 10.3390/v3060677
关键词
Murine Leukemia Virus; gammaretroviral; split packaging design; SIN vector
类别
资金
- Deutsche Forschungsgemeinschaft [SFB738]
- Bundesministerium fur Bildung und Forschung (BMBF)
- DAAD (Modern Applications in Biotechnology)
- European Union
Retroviruses are evolutionary optimized gene carriers that have naturally adapted to their hosts to efficiently deliver their nucleic acids into the target cell chromatin, thereby overcoming natural cellular barriers. Here we will review-starting with a deeper look into retroviral biology-how Murine Leukemia Virus (MLV), a simple gammaretrovirus, can be converted into an efficient vehicle of genetic therapeutics. Furthermore, we will describe how more rational vector backbones can be designed and how these so-called self-inactivating vectors can be pseudotyped and produced. Finally, we will provide an overview on existing clinical trials and how biosafety can be improved.
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